“Given this innovative vaccine platform, we examined the bio-distribution of the mRNA vaccines for both routes of administration. Male CD-1 mice received 6mg formulated H10 mRNA either IM or ID. Following IM administration, the maximum concentration (Cmax) of the injection site muscle was 5,680 ng/mL, and the level declined with an estimated t1/2 of 18.8 hr (Table 1). Proximal lymph nodes had the second highest concentration at 2,120 ng/mL (tmax of 8 hr with a relatively long t1/2 of 25.4 hr), suggesting that H10 mRNA distributes from the injection site to systemic circulation through the lymphatic system. The spleen and liver had a mean Cmaxof86.9 ng/mL (area under the curve [AUC]0–264of 2,270 ng.hr/mL)and 47.2 ng/mL (AUC0–264of 276 ng.hr/mL), respectively. In the remaining tissues and plasma, H10 mRNA was found at 100- to1,000-fold lower levels.” (Mol Ther. 2017 Jun 7;25(6):1316-1327. doi: 10.1016/j.ymthe.2017.03.035. Epub 2017 Apr 27.)
“IM injections yielded expression at the injection site (68%), liver (12%), and kidneys (11%). " (Nano Lett. 2020 Jul 8;20(7):5167-5175. doi: 10.1021/acs.nanolett.0c00596. Epub 2020 Jun 9.)
“When mRNA-LNPs were injected intramuscularly and intratracheally, similar to intravenous and intraperitoneal deliveries, a large portion of the luciferase activity was detectable in the liver, demonstrating systemic spread of the nanoparticles. Also similar to intravenous and intraperitoneal deliveries, the high levels of protein produced in the liver occurred over a short duration with the majority of translation ceasing at day 2 post-injection (Fig. 2). Interestingly, significant bioluminescent signal could be measured in the lungs and muscles, as well, with the latter lasting for up to 8 days post injection.” (J Control Release. 2015 Nov 10;217:345-51. doi: 10.1016/j.jconrel.2015.08.007. Epub 2015 Aug 8.)
Of additional concern, the standard of administration (both by manufacturers and public health entities) does not include aspiration of the syringe (to determine if the needle has entered a blood vessel) before administering the injection. If the injection is properly placed, this is a rare occurance. However it could lead to greater systemic spread if injected directly into the bloodstream.
This summary of above findings were aggregated by a respondent (see comments section) to the following article: https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids (a good discussion of both sides of the question are found here).
Furthermore, as Dr Jim Meehan, MD, discussed in his "Emergency Declaration" email:
"Introduction of spike proteins to in vitro models of the blood-brain barrier (BBB) showed significant changes to barrier properties. Key to our findings is the demonstration that S1 promotes loss of barrier integrity in an advanced 3D microfluidic model of the human BBB, a platform that more closely resembles the physiological conditions at this CNS interface. Evidence provided suggests that the SARS-CoV-2 spike proteins trigger a pro-inflammatory response on brain endothelial cells that may contribute to an altered state of BBB function. Together, these results are the first to show the direct impact that the SARS-CoV-2 spike protein could have on brain endothelial cells; thereby offering a plausible explanation for the neurological consequences seen in COVID-19 patients."
These facts taken together would indicate that a second follow-up dose of these mRNA vaccines would potentially cause even more neurological risk due to the initial shot compromising the Blood Brain Barrier, thus allowing much more mRNA to cross into the nervous tissue and bring about the MHC-Spike Protein tagging in effected cells.
Why is this significant? As I reported previously:
"according to my research, producing the Covid-19 spike protein as a “self” protein means it is eventually encoded into the outer cell membrane (as MHC-I molecules). These tell T-cells to attack and destroy upon discovery… And it may take time for this to occur and symptoms to manifest. I saw a comment recently in a scientific forum that we will see an epidemic of ALS and MS if the mRNA gets past the blood brain barrier. At the very least disorder of hypothalamic function. Also that the mRNA can diffuse into the organ parenchyma (unlike COVID-19 itself) thus setting up for organ-specific autoimmune disease."
So if you haven’t taken the second dose… Pray about it and make an informed decision. Remember that your health is your responsibility. According to a Olga, T Jonas, a Senior Advisor to the World Bank, many will fall for the “myth" that “Health authorities will protect us from pandemics”
Furthermore, we have but to look to the past to realize that governmental entities are not infallible in terms of public health intervention during pandemics. In the 1918 Avian Influenza Pandemic the US government reportedly “badly mishandled the epidemic,” “control[led] public perception” with domestic propaganda with restrictions on freedoms of speech (enforced by the threat of lengthy incarceration), and the telling of “half-truths or outright lies.” Furthermore, this propaganda found a welcome abode with the free press “which although not censored in a technical sense cooperated fully with the government’s propaganda machine.” -Institute of Medicine. 2005. The Threat of Pandemic Influenza: Are We Ready? Workshop Summary. Washington, DC: The National Academies Press. https://doi.org/10.17226/11150.
And lastly, here are a few things that I would do myself if I desired to reduce neuroinflammation: (disclaimer: this is not intended as doctor-client personalized medical advice)
1) Trust that God is able to heal any disease or health condition if it is His will to do so (Matthew 9:35).
2) Establish a regular early bedtime (this is when the brain heals itself) maximizing delta wave and REM sleep stages. Please watch my YouTube video on this subject: https://youtu.be/0GJjGJnf9gY. This video is an important starting place as deep sleep (delta wave sleep) is when the brain actually heals. Many people with neuroinflammation or degenerative brain diseases are deficient in this type of sleep.
3) Sometimes prescription drugs are used to increase alter neurotransmitter levels than may be contributing to the cognitive disturbance (especially “acetylcholinesterase inhibitors”). Due to the side effects of the pharmacologic acetylcholinesterase inhibitors, I would personally go for the natural alternatives.
a) Lemon peel essential oil, in small doses, was just as effective as the pharmaceutical prostigmine (an acetylcholenstease inhibitor) J Oleo Sci. 2014;63(4):373-81. I would cut an organic lemon into small slices and eat at least one slice of lemon peel, organic, per day. Or I might take a couple drops of lemon essential oil (food grade) and drink with a small glass of lemonade :) Yum!
b) Sage essential oil has also shown potential in this area. However one study revealed “there is a major synergistic effect among the constituents.” This would indicate that the components of the whole oil work together to bring about the acetylcholinesterase inhibition. (2a) J Pharm Pharmacol. 2000 Jul;52(7):895-902. Sage oil could be diluted with a carrier oil like coconut and rubbed onto the hands and feet, the skin’s most porous areas, to be absorbed into the circulation.
c) Alpha and Beta Pinene (found in abundance in many evergreen essential oils- especially pine scotch and rosemary essential oil) have been shown to very effectively cross the blood-brain barrier and therapeutically block the action of acetylcholesterase. (3a) Nat Prod Res. 2015 Feb;29(3):213-22. doi: 10.1080/14786419.2014.942305. I would use these oils as inhalants (using an ultrasonic vaporizer).
4) Go on an antiviral/ and possibly even a mild anticancer regimen. Both viral infection and cancer can lead to neuroinflammation. This occurrence (viral cause) may be more common than we would think. Aside from Covid-19 infection, many viruses can have neurological side effects. For instance, West Nile virus has been shown to cause low grade encephalitis and is commonly carried by mosquitos in North America. Also, even a low grade varicella (chicken pox or shingles) infection can cause localized neuroinflammation. The use of the pine essential oil as inhalant is potentially a huge boost to the efforts here. Also, I would take oregano oil (comes in capsules if you do not appreciate the burning sensation of swallowing this prediluted essential oil blend). Carvacrol, the active component in this oil is amazing in it’s ability to fight many types of viral threats. I would also consider using elderberry extract daily.
5) Go gluten-free. I know this sounds difficult, but if you actually have a gluten sensitivity and you are eating gluten you will potentially develop neurodegeneration that could lead to cognitive impairment. As a trial, a couple weeks of a GF diet should bring some improvement. Here is the study that references this possibility: J Neurol Neurosurg Psychiatry. 2002 May; 72(5): 560–563.
6) Use turmeric and honey mixture daily to reduce neuroinflammation.Studies have shown this amazing root may significantly reduce inflammation. Turmeric's active compounds block production of two of the bodies' inflammatory substances: prostaglandin E2 and leukotrienes. For best absorbency of the active compounds in this root, I combine 1 tsp turmeric powder with 1 tsp honey, form a paste and chew thoroughly (30 sec to 1 min) before meals. I know a turmeric capsule would be easier but you actually absorb any food better if it is mixed well with saliva. Furthermore, studies reveal absorption of the anti-inflammatory compounds begin in the mouth. Clin Cancer Res. 2011 Sep 15;17(18):5953-61. doi: 10.1158/1078-0432.CCR-11-1272.
Using a sweetener (honey in this mixture) helps to open channels in the blood brain barrier allowing for increased uptake of anti-inflammatory curcumin compounds.
I like to make a paste with 1 tsp liquid sunflower lecithin, 1 tsp turmeric, and 1 tsp honey. Mixture should be chewed thoroughly to increase absorbency of active ingredients. This provides a potent blend of anti-inflammatory action along with building blocks for encouraging brain recovery.
7) Heal the gut (endotoxins such as Lipopolysaccarides (LPS) can easily cause cognitive impairment). See my 4-part series on this subject here: https://www.youtube.com/watch?v=HfIlATsifEc
8) Detoxify the blood. Chlorella is a potent eliminator of heavy metals, like mercury, that can cause issues with nervous function. The chlorella can be taken with water or just simply chewed as well (in tablet form).
9) Engage in a regular (daily) moderate exercise regimen - studies have shown this increases blood flow to the hippocampus (memory center of the brain) and long term benefits include an increase in actual size and capacity of the hippocampus. This would indicate an enhancement in memory function. Walking is a good option.
10) Last, but not least, get more Oxytocin (the Love hormone). Studies looking at nasal administration of oxytocin showed a reduction in apathy among individuals with dementia. However, we have a natural source of this amazing compound: loving, trusting relationships. Ther Adv Psychopharmacol. 2017 Jan;7(1):48-53. doi: 10.1177/2045125316672574.